Long-term observational follow-up study of breast cancer diagnosed in women ≤40 years old

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• 作者：Peeter Karihtala ; Robert Winqvist ; Risto Bloigu ; Arja Jukkola-Vuorinen
• 关键词：Breast cancer ; Estrogen receptor ; Hormone therapy ; Lymph node ratio ; Survival ; Young
• 刊名：The Breast
• 出版年：2010
• 出版时间：December 2010
• 年：2010
• 卷：19
• 期：6
• 页码：456-461
• 全文大小：318 K

文摘

The prognosis of young breast cancer patients has been considered to be much poorer than in older patients. Two hundred and sixty-eight premenopausal women with a median follow-up time of 74.0 months were included in the study. 33.5 % had oestrogen receptor-negative and 34.6 % progesterone receptor-negative tumours. 15.2 % of the tumours were HER2-positive. Five-year breast cancer-specific survival (BCSS) was 81.1 % and the corresponding 10-year figure was 72.3 % . 91.8 % of all relapses occurred within seven years of surgery. Among the ≤35-year-old women, only 2 of 38 (5.3 % ) relapsed beyond seven years of follow-up. Lymph node ratio was the most significant independent prognostic factor of poor disease-free survival and BCSS. This study revealed a high relapse rate in the youngest women as early as during the first few years after diagnosis, although their prognosis as a whole was surprisingly good.