Human peripheral late/exhausted memory B cells express a senescent-associated secretory phenotype and preferentially utilize metabolic signaling pathways

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• 作者：Daniela Frasca ; ^{dfrasca@med.miami.edu} ; Alain Diaz ; Maria Romero ; Bonnie B. Blomberg
• 关键词：Aging ; B cells ; Inflammation ; Vaccine responses ; SASP
• 刊名：Experimental Gerontology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：87
• 期：part_PA
• 页码：113-120
• 全文大小：880 K
• 卷排序：87

文摘

Percentages of late/exhausted memory (LM) B cells increase with age. LM B cells are associated with a lower influenza vaccine response. LM B cells express multiple senescence-associated secretory phenotype markers. LM B cells preferentially signal through AMPK.