RFWD3-Dependent Ubiquitination of RPA Regulates Repair at Stalled Replication Forks
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- 作者：Andrew E.H. Elia1 ; 2 ; David C. Wang1 ; 2 ; Nicholas A. Willis3 ; Alexander P. Boardman1 ; 2 ; Ildiko Hajdu1 ; Richard O. Adeyemi1 ; Elizabeth Lowry1 ; 2 ; Steven P. Gygi4 ; Ralph Scully3 ; Stephen J. Elledge1 ; selledge@genetics.med.harvard.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Molecular Cell
- 出版年：2015
- 出版时间：15 October 2015
- 年：2015
- 卷：60
- 期：2
- 页码：280-293
- 全文大小：2958 K
文摘
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RPA is ubiquitinated on chromatin in response to replication fork stalling
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Ubiquitination of RPA is mediated by the E3 ligase RFWD3
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RFWD3 promotes replication fork restart and homologous recombination at stalled forks
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Multisite ubiquitination of the entire RPA complex is necessary for HR