Performance of 尾-tricalcium phosphate granules and putty, bone grafting materials after bilateral sinus floor augmentation in humans

详细信息    查看全文

• 作者：Michael Stiller ; Esther Kluk ; Marc Bohner ; Marco A. Lopez-Heredia ; Christian M眉ller-Mai ; Christine Knabe
• 关键词：Sinus floor augmentation ; Split-mouth design ; 尾-TCP bone graft ; Granules ; Putty
• 刊名：Biomaterials
• 出版年：March, 2014
• 年：2014
• 卷：35
• 期：10
• 页码：3154-3163
• 全文大小：1887 K

文摘

Sinus floor augmentation (SFA) using bone grafting materials, and in particular calcium phosphates (CaP), is a well-established pre-implantology procedure. The use of CaP simplifies SFA procedures. 尾-tricalcium phosphate (尾-TCP) is amply used for SFA. This study evaluated the clinical and osteogenic performance of 尾-TCP granules (TCP-G) and a 尾-TCP putty (TCP-P) bone graft material. TCP-P consisted of TCP-G in a hyaluronic acid (HyA) carrier. Bone formation, volume stability and osteogenic marker expression after bilateral SFA in patients was assessed. Eight patients were selected for a split-mouth design. Biopsies obtained six months after SFA, were processed for immunohistochemical analysis of collagen type I (Col聽I), alkaline phosphatase (ALP), osteocalcin (OC) and bone sialoprotein (BSP). Histomorphometric analysis determined bone, grafting material and marrow space percentages. Cone-beam computed tomography was used to calculate the graft volume and its stability. Both materials allowed excellent bone regeneration and volume stability. TCP-P displayed better surgical handling properties, greater bone formation, higher expression of Col I, ALP, OC and BSP; as well as significantly lower grafting volume reduction values. HyA had no adverse effect on TCP-P performance. Due to its clinical and osteogenic performance, TCP-P can be regarded as excellent bone grafting material for SFA.