Early dose-dependent cortical thinning of the femoral neck in anal cancer patients treated with pelvic radiation therapy

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• 作者：Catherine Okoukoni ; B.Eng.^a ; ^b ; David M. Randolph ; MD^a ; ^d ; Emory R. McTyre ; MS ; MD^a ; ^d ; Andy Kwok ; BS^a ; Ashley A. Weaver ; PhD^b ; ^c ; A. William Blackstock ; MD^a ; ^d ; Michael T. Munley ; PhD^a ; ^b ; ^d ; Jeffrey S. Willey ; PhD^a ; ^d ; ^{jwilley@wakehealth.edu}
• 关键词：RT ; radiation therapy ; IMRT ; intensity modulated radiation therapy ; CT ; computed tomography ; Ct.Th ; cortical thickness ; FN ; femoral neck ; trBMD ; trabecular bone mineral density ; CRT ; chemo-radiation therapy ; SCC ; squamous cell carcinoma ; SEER ; Surveillance ; Epidemiology ; and End Results ; OARs ; organs at risk ; RTOG ; Radiation Therapy Oncology Group ; SBRT ; stereotactic body radiation therapy ; DICOM ; Digital Imaging and Communications in Medicine ; BMI ; body mass index ; ECOG PS ; Eastern Cooperative
• 刊名：Bone
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：94
• 期：Complete
• 页码：84-89
• 全文大小：776 K
• 卷排序：94

文摘

The proximal femur absorbs a large radiation dose in anal cancer patients treated with radiation therapy (RT). Rapid, dose-dependent cortical thinning and BMD loss was observed in the inferior femoral neck (FN) of anal cancer patients. FN volume receiving ≥ 40 Gy (V40Gy) was a significant predictor of clinically significant focal cortical bone thinning.