Metabolite profiling of sex developmental steroid conjugates reveals an association between decreased levels of steroid sulfates and adiposity in obese girls
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- 作者：Su Hyeon Leea ; b ; Shin Hye Kimc ; Won-Yong Leeb ; Bong Chul Chunga ; Mi Jung Parkc ; Man Ho Choia ; mh_choi@kist.re.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Steroids ; Glucuronide ; Sulfate ; LC&ndash ; MS ; Obesity ; Adiposity
- 刊名：Journal of Steroid Biochemistry and Molecular Biology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：162
- 期：Complete
- 页码：100-109
- 全文大小：603 K
文摘
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LC–MS-based analysis of 16 steroid sulfates and glucuronides was developed.
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LC-SIM-MS method with ion-trap analyzer was fully validated.
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Serum steroid sulfates were significantly altered in obese girls.
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Changed serum levels of steroid sulfates were correlated with adiposity.