α-Phenyl-N-tert-butyl nitrone (PBN) derivatives: Synthesis and protective action against microvascular damages induced by ischemia/reperfusion

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• 作者：Sothea Kim ; Guilherme V.M. de A. Vilela ; Jalloul Bouajila ; Ayres G. Dias ; Fatima Z.G.A. Cyrino ; Eliete Bouskela ; Paulo R.R. Costa ; Franç ; oise Nepveu
• 关键词：PBN derivatives ; Protective action against microvascular damages ; Ischemia/reperfusion
• 刊名：Bioorganic and Medicinal Chemistry
• 出版年：2007
• 出版时间：15 May 2007
• 年：2007
• 卷：15
• 期：10
• 页码：3572-3578
• 全文大小：186 K

文摘

Nitrones 4–7, structurally related to PBN (1), were prepared by reaction of the corresponding aromatic aldehydes with N-tert-butyl hydroxylamine. The protective effects of these nitrones against microvascular damages in ischemia/reperfusion in the ‘hamster cheek pouch’ assay were studied and 1, as well as 4a, 4b, and 7 (derived from piperonal, O-benzyl vanillin, and furfural, respectively), showed to be more active than shark cartilage or α-tocopherol. No correlation was found between the protective effect of these nitrones and their log P (partition coefficient) or their capacity to trap ^·OH and ^·CH₃ radicals.