Associations between common polymorphisms of adenosine triphosphate-binding cassette transporter A1 and coronary artery disease in a Tunisian population

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• 作者：Jihè ; ne Rejeb ; Asma Omezzine ; Lamia Rebhi ; Imen Boumaiza ; Kaouthar Kchock ; Radhia Belkahla ; Nabila Ben Rejeb ; Naoufel Nabli ; Ahmed Ben Abdelaziz ; Essia Boughzala ; Ali Bouslama
• 关键词：ABCA1 polymorphisms ; Coronary artery disease ; Haplotype ; Tunisian
• 刊名：Archives of Cardiovascular Diseases
• 出版年：2010
• 出版时间：October 2010
• 年：2010
• 卷：103
• 期：10
• 页码：530-537
• 全文大小：184 K

文摘

Summary

Background

The adenosine triphosphate-binding cassette transporter A1 (ABCA1) protein plays an important role in the first step of the reverse cholesterol transport system.

Aims

We studied the association of four polymorphisms in the ABCA1 gene (G1051A, G2706A, G2868A and –565C/T) with lipid profile and coronary artery disease.

Methods

Overall, 316 Tunisian patients underwent coronary angiography. Genotyping was performed using polymerase chain reaction-restriction fragment length polymorphism analysis. Lipid and apolipoprotein concentrations were measured.

Results

Only carriers of the G2706A allele were associated with a decreased risk of significant stenosis (odds ratio [OR] 0.66, 95 % confidence interval [CI] 0.22–0.92, p = 0.029), without pronounced effects on high-density lipoprotein (HDL) cholesterol. This protective effect was significant in smokers and diabetes. Carriers of the G1051A allele were associated only with increased concentrations of HDL cholesterol (p = 0.032). G2868A and –565C/T did not show any association with lipids or risk of significant stenosis. When ABCA1 polymorphisms were combined in haplotypes possessing G1051A, G2706A, G2868A and –565C/T, (AAGC) seemed to be most protective against significant stenosis (OR 0.5, 95 % CI 0.29–0.96, p = 0.048) whereas (GGAT) was probably the most atherogenic (OR 1.26, 95 % CI 1.03–1.56, p = 0.025).

Conclusion

Only the G2706A allele seems to be associated with a reduced risk of significant stenosis without important modification of HDL-cholesterol concentration, and appears to be more protective for smokers and diabetic patients. We found that (AAGC) seems to be a protective haplotype whereas (GGAT) has an atherogenic effect in a Tunisian population.