Is profound hypothermia required for storage of cardiac allografts?

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• 作者：Vivek Rao ; Christopher M. Feindel ; Gideon Cohen ; Michael A. Borger ; Patty Boylen ; Heather J. Ross
• 关键词：16 ; 17
• 刊名：The Journal of Thoracic and Cardiovascular Surgery
• 出版年：2001
• 出版时间：September 2001
• 年：2001
• 卷：122
• 期：3
• 页码：501-507
• 全文大小：112 K

文摘

Background: Improved methods of cardiac allograft protection are required to expand the pool of potentially available organs and to enhance the recovery of grafts subjected to prolonged ischemia. We have previously demonstrated that limited coronary perfusion provided by donor blood harvested at the time of organ procurement can improve both metabolic and functional recovery after transplantation. In this study we evaluated the hypothesis that limited coronary perfusion may enable prolonged cardiac storage while avoiding the potentially detrimental effects of profound hypothermia. Methods: Fourteen orthotopic cardiac transplants were performed in female Yorkshire pigs by using donor blood perfusion during 5 hours of either tepid (25°C) or cold (4°C) storage. Assessments of myocardial metabolism and function were performed at baseline and after 45 minutes of normothermic (37°C) reperfusion. Results: Hearts protected with tepid perfusion displayed improved recovery of myocardial function (89 % ± 18 % vs 63 % ± 25 % , P = .05). Diastolic compliance was adversely affected in both groups after transplantation. Aerobic myocardial metabolism was better preserved in the tepid group. Conclusions: Profound hypothermia results in depressed myocardial metabolic and functional recovery after transplantation. Limited coronary perfusion with shed donor blood can permit cardiac allograft storage at tepid temperatures, resulting in improved myocardial performance.