Different implication of NEDD9 genetic variant in early and late-onset Alzheimer's disease

详细信息    查看全文

• 作者：Andrea Tedde ; Silvia Bagnoli ; Irene Piaceri ; Ersilia Lucenteforte ; Valentina Bessi ; Laura Bracco ; Aless ; ro Mugelli ; S ; ro Sorbi ; Benedetta Nacmias
• 关键词：NEDD9 ; Alzheimer's disease ; Genetic variant ; Apolipoprotein E
• 刊名：Neuroscience Letters
• 出版年：2010
• 出版时间：25 June 2010
• 年：2010
• 卷：477
• 期：3
• 页码：121-123
• 全文大小：126 K

文摘

Alzheimer's disease (AD) is a complex and multifactorial progressive neurodegenerative disease. Recently, two studies reported inconsistent results on a possible involvement of the NEDD9 (neural precursor cell expressed, developmentally down-regulated 9, 6p25-p24) as a candidate gene for the risk of developing AD and/or Parkinson's disease (PD). We analyzed the distribution of the rs760678 SNP polymorphism in 735 Italian subjects: 214 unrelated sporadic late-onset AD patients (LOAD, 64.5 % females, mean age-at-onset 71.8 ± 5.2 years), 135 early-onset AD patients (EOAD, 57.3 % females, mean age-at-onset 57.5 ± 5.5 years) and 386 healthy controls (68.9 % females, mean age 83.4 ± 17.9 years; SD). We observed a statistically significant difference between LOAD patients and controls according to genotypes (P = 0.016) and allele frequency (P = 0.007); CC genotype was more frequent in LOAD cases (44.4 % ) than controls (36.0 % ). No difference after stratification of the data in terms of gender and status of the APOE 4 allele was observed. In conclusion, our data do support an implication of the NEDD9 allelic variant in late-onset AD, with an independent effect of the apolipoprotein E (APOE) 4 allele in the risk of developing AD.