In vitro fertilization surrogate pregnancy in a patient who underwent radical hysterectomy followed by ovarian transposition, lower abdominal wall radiotherapy, and chemotherapy

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• 作者：Stephen Steigrad ; Neville F. Hacker ; Bradford Kolb
• 关键词：Ovarian transposition ; premature ovarian failure ; surrogate pregnancy ; IVF ; hysterectomy
• 刊名：Fertility and Sterility
• 出版年：2005
• 出版时间：May 2005
• 年：2005
• 卷：83
• 期：5
• 页码：1547.e7-1547.e9
• 全文大小：55 K

文摘

Objective

To describe an IVF surrogate pregnancy from a patient who had a radical hysterectomy followed by excision of a laparoscopic port site implantation with ovarian transposition followed by abdominal wall irradiation and chemotherapy, which resulted in premature ovarian failure from which there was partial recovery.

Design

Case report.

Setting

Tertiary referral university women's hospital in Sydney, Australia and private reproductive medicine clinic in California.

Patient(s)

A 34-year-old woman who underwent laparoscopy for pelvic pain, shortly afterward followed by radical hysterectomy and pelvic lymph node dissection, who subsequently developed a laparoscopic port site recurrence, which was excised in association with ovarian transposition before abdominal wall irradiation and chemotherapy.

Intervention(s)

Modified IVF treatment, transabdominal oocyte retrieval, embryo cryopreservation in Australia, and transfer to a surrogate mother in the United States.

Main Outcome Measure(s)

Pregnancy.

Result(s)

Miscarriage in the second cycle and a twin pregnancy in the fourth cycle.

Conclusion(s)

This is the first case report of ovarian stimulation and oocyte retrieval performed on transposed ovaries after a patient developed premature ovarian failure after radiotherapy and chemotherapy with subsequent partial ovarian recovery.