- 作者：Hidetake Yabuuchi ; Yoshio Matsuo ; Takeshi Kamitani ; Taro Setoguchi ; Takashi Okafuji ; Hiroyasu Soeda ; Shuji Sakai ; Masamitsu Hatakenaka ; Makoto Kubo ; Eriko Tokunaga ; Hidetaka Yamamoto ; Hiroshi Honda
- 关键词：Non-mass-like enhancement ; Breast MRI ; Diffusion-weighted MR images ; Dynamic contrast-enhanced MR images ; ADC
- 刊名：European Journal of Radiology
- 出版年：2010
- 出版时间：July 2010
- 年：2010
- 卷：75
- 期：1
- 页码：e126-e132
- 全文大小：753 K
PurposeTo evaluate the diagnostic accuracy of a combination of dynamic contrast-enhanced MR imaging (DCE-MRI) and diffusion-weighted MR imaging (DWI) in characterization of lesions showing non-mass-like enhancement on breast MR imaging and to find the strongest discriminators between carcinoma and benignancy.Materials and methods
We analyzed consecutive MR images in 45 lesions showing non-mass like enhancement in 41 patients. We analyzed lesion size, distribution, internal enhancement, kinetic curve pattern, and apparent diffusion coefficient (ADC) values. We applied univariate and multivariate analyses to find the strongest indicators for malignancy. In a validation study, 22 non-mass-like enhancement lesions in 21 patients were examined. We calculated diagnostic accuracy when we presume category 4b, 4c, and 5 lesions as malignant or high to moderate suspicion for malignancy, and category 4a and 3 as low suspicion for malignancy or benign.
Results
Segmental distribution (P = 0.018), clumped internal enhancement (P = 0.005), and ADC less than 1.3 × 10−3 mm2/s (P = 0.047) were the strongest MR indicators of malignancy. In a validation study, sensitivity, specificity, positive predictive value, negative predictive value and accuracy were 87 % (13/15), 86 % (6/7), 93 % (13/14), 75 % (6/8) and 86 % (19/22), respectively.
Conclusion
The combination of DCE-MRI and DWI showed high diagnostic accuracy in characterization of non-mass-like enhancement lesions on breast MR images.