An In-Vivo Study of the Wound-Bursting Strengths of Octyl-Cyanoacrylate, Butyl-Cyanoacrylate, and Surgical Tape in Rats
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- 作者：Breena R. Taira ; Adam J. Singer ; Jean Rooney ; Nicole T. Steinhauff ; Thomas Zimmerman
- 刊名：Journal of Emergency Medicine
- 出版年：2010
- 出版时间：May 2010
- 年：2010
- 卷：38
- 期：4
- 页码：546-551
- 全文大小：500 K
文摘
Background: Several non-invasive wound-closure devices are available. Clinical studies of low-tension lacerations suggest similar clinical outcomes with these devices. Objective: We compared the wound-bursting strengths (WBS) of octyl-cyanoacrylate (Dermabond), butyl-cyanoacrylate (Histoacryl Blue), and adhesive tape (Steri-Strips). Methods: Design—randomized, controlled, blinded experiment. Setting—university-based division of laboratory animal research. Subjects—15 Sprague-Dawley rats weighing 250–350 g. Interventions—standardized 2-cm full-thickness incisions were made in duplicate on both sides of the rat's dorsum with a #15 surgical blade and closed with one of the three study wound-closure devices following manufacturer instructions. The order of closure was randomized. Measurements—WBS was measured after wound closure with a validated vacuum-controlled wound chamber device (BT-2000) that measures the pressure required to disrupt the closed wound. Data analysis—between-group comparisons were performed with pair-wise t-tests and chi-squared tests. This study had 80 % power to detect a 75-mm Hg between-group difference in WBS (two-tailed α = 0.05). Results: We evaluated 30 incisions in 15 rats. The mean WBS of octyl-cyanoacrylate (298 ± 58 mm Hg) was significantly higher than that of butyl-cyanoacrylate (199 ± 87 mm Hg; difference 98 mm Hg [95 % confidence interval (CI) 32–165], p = 0.006) or Steri-Strips (129 ± 67 mm Hg; difference 169 mm Hg [95 % CI 112–227], p < 0.001). The WBS of butyl-cyanoacrylate was stronger than that of Steri-Strips; difference 71 mm Hg (95 % CI 4–138), p = 0.035. Conclusions: Octyl-cyanoacrylate tissue adhesive has a higher WBS than butyl-cyanoacrylate, whose WBS is greater than that of surgical tape.