Low dose assessment of the carcinogenicity of furan in male F344/N Nctr rats in a 2-year gavage study

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• 作者：Linda S. Von Tungeln^a ; Nigel J. Walker^b ; Greg R. Olson^c ; Maria C.B. Mendoza^d ; Robert P. Felton^d ; Brett T. Thorn^d ; ¹ ; M. Matilde Marques^e ; Igor P. Pogribny^a ; Daniel R. Doerge^a ; Frederick A. Beland^a ; ^{frederick.beland@fda.hhs.gov}
• 关键词：Furan ; Tumorigenicity ; Cholangiocarcinoma ; Cholangiofibrosis ; Rats ; Bioassay
• 刊名：Food and Chemical Toxicology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：99
• 期：Complete
• 页码：170-181
• 全文大小：1273 K
• 卷排序：99

文摘

Furan is a contaminant in many common foods. The carcinogenicity of furan was assessed in male F344/N rats. Exposure to furan induced malignant mesothelioma and mononuclear cell leukemia. The most sensitive non-neoplastic lesion was cholangiofibrosis.