Crystal Structure of a Full-Length Human Tetraspanin Reveals a Cholesterol-Binding Pocket
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- 作者：Brandon Zimmerman1 ; 2 ; Brendan Kelly3 ; Brian J. McMillan1 ; 2 ; Tom C.M. Seegar1 ; 2 ; Ron O. Dror3 ; Andrew C. Kruse1 ; andrew_kruse@hms.harvard.edu" class="auth_mail" title="E-mail the corresponding author ; Stephen C. Blacklow1 ; 2 ; 4 ; 5 ; stephen_blacklow@hms.harvard.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：CD81 ; CD19 ; membrane protein ; X-ray crystallography ; protein structure ; protein trafficking
- 刊名：Cell
- 出版年：2016
- 出版时间：3 November 2016
- 年：2016
- 卷：167
- 期：4
- 页码：1041-1051.e11
- 全文大小：7321 K
文摘
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The structure of full-length CD81 reveals a cone-like architecture
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A large intramembrane cavity exists within the transmembrane region
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Cholesterol binds CD81 within the intramembrane cavity
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MD simulations suggest that CD81 can adopt open and closed conformations