Therapies negating neuroinflammation after brain trauma
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- 作者：Sarah Hellewella ; hellewel@ualberta.ca" class="auth_mail" title="E-mail the corresponding author ; Bridgette D. Sempleb ; Bridgette.Semple@unimelb.edu.au" class="auth_mail" title="E-mail the corresponding author ; Maria Cristina Morganti-Kossmannc ; d ; cristina.morganti-kossmann@monash.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Traumatic brain injury ; Neurotrauma ; Neuroinflammation ; Neuroprotection ; Cytokine ; Chemokine
- 刊名：Brain Research
- 出版年：2016
- 出版时间：1 June 2016
- 年：2016
- 卷：1640
- 期：part_PA
- 页码：36-56
- 全文大小：778 K
文摘
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Inflammation is a crucial component of the secondary response to TBI.
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Neuroprotective trials have failed due to widespread immune suppression.
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Targeted immunotherapies at critical times would yield the most promising results.
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Several single and multifunctional drugs have preclinical indications of success.