New cytotoxic compounds of endophytic fungus Alternaria sp. isolated from Broussonetia papyrifera (L.) Vent

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• 作者：Naidan Zhang¹ ; Chunyan Zhang¹ ; Xiao Xiao ; Qiaoyan Zhang ; Baokang Huang ; ^{hbkcn@163.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Endophytic fungi ; Alternaria ; Altertoxin IV ; Broussonetia papyrifera ; Cytotoxic activity
• 刊名：Fitoterapia
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：110
• 期：Complete
• 页码：173-180
• 全文大小：1255 K

文摘

From the ethyl acetate extract of a culture of the endophytic fungus Alternaria species G7 in Broussonetia papyrifera, a new compound altertoxin IV (1) together with nine known compounds were isolated and identified by means of bioassay-guided fractionation. The structures of these compounds were established on the basis of spectroscopic methods, among which the absolute configuration of compound 1, a new tetrahydroperylenone derivative, was determined by means of X-Ray Crystallographic analysis. The isolated compounds were subjected to cytotoxic activity against three human cancer cell lines (A549, MG-63, and SMMC-7721). Compound 2 showed significant cytotoxic activities against tested cell lines, with IC₅₀ values of 1.47, 2.11 and 7.34 μg/mL, respectively. Additionally, compound 4 also exhibited significant cytotoxic activities against cell lines MG-63 and SMMC-7721, with IC₅₀ values of 0.53 and 2.92 μg/mL. Endophytic fungi Alternaria from B. papyrifera might be promising sources of natural bioactive and novel metabolites.