Dual-frequency magnetic particle imaging of the Brownian particle contribution
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- 作者：Thilo Viereck ; t.viereck@tu-bs.de ; Christian Kuhlmann ; Sebastian Draack ; Meinhard Schilling ; Frank Ludwig
- 关键词：Magnetic particle imaging ; Magnetic nanoparticles ; Brownian and Né ; el relaxation
- 刊名：Journal of Magnetism and Magnetic Materials
- 出版年：2017
- 出版时间：1 April 2017
- 年：2017
- 卷：427
- 期：Complete
- 页码：156-161
- 全文大小：839 K
- 卷排序：427
文摘
Magnetic particle imaging (MPI) is an emerging medical imaging modality based on the non-linear response of magnetic nanoparticles to an exciting magnetic field. MPI has been recognized as a fast imaging technique with high spatial resolution in the mm range. For some applications of MPI, especially in the field of functional imaging, the determination of the particle mobility (Brownian rotation) is of great interest, as it enables binding detection in MPI. It also enables quantitative imaging in the presence of Brownian-dominated particles, which is otherwise implausible. Discrimination of different particle responses in MPI is possible via the joint reconstruction approach. In this contribution, we propose a dual-frequency acquisition scheme to enhance sensitivity and contrast in the detection of different particle mobilities compared to a standard single-frequency MPI protocol. The method takes advantage of the fact, that the magnetization response of the tracer is strongly frequency-dependent, i.e. for low excitation frequencies a stronger Brownian contribution is observed.