Oesophagus side effects related to the treatment of oesophageal cancer or radiotherapy of other thoracic malignancies

详细信息    查看全文

• 作者：Sonja Adebahr ; MD^a ; ^b ; ^{sonja.adebahr@uniklinik-freiburg.de" class="auth_mail" title="E-mail the corresponding author} (Research Fellow) ; Tanja Schimek-Jasch ; MD^a ; ^{tanja.schimek-jasch@uniklinik-freiburg.de" class="auth_mail" title="E-mail the corresponding author} (Research Fellow) ; Ursula Nestle ; MD ; PhD^a ; ^b (Professor) ; Thomas B. Brunner ; MD ; PhD^a ; ^b ; ^{thomas.brunner@uniklinik-freiburg.de" class="auth_mail" title="E-mail the corresponding author} (Professor)
• 关键词：Oesophagus toxicity ; Chemoradiotherapy ; Gastrointestinal cancer ; Radiotherapy ; Stereotactic body radiotherapy (SBRT)
• 刊名：Best Practice & Research Clinical Gastroenterology
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：30
• 期：4
• 页码：565-580
• 全文大小：626 K

文摘

The oesophagus as a serial organ located in the central chest is frequent subject to “incidental” dose application in radiotherapy for several thoracic malignancies including oesophageal cancer itself. Especially due to the radiosensitive mucosa severe radiotherapy induced sequelae can occur, acute oesophagitis and strictures as late toxicity being the most frequent side-effects. In this review we focus on oesophageal side effects derived from treatment of gastrointestinal cancer and secondly provide an overview on oesophageal toxicity from conventional and stereotactic fractionated radiotherapy to the thoracic area in general. Available data on pathogenesis, frequency, onset, and severity of oesophageal side effects are summarized. Whereas for conventional radiotherapy the associations of applied doses to certain volumes of the oesophagus are well described, the tolerance dose to the mediastinal structures for hypofractionated therapy is unknown. The review provides available attempts to predict the risk of oesophageal side effects from dosimetric parameters of SBRT.