A novel IL modified CCC pretreatment method was developed.
It can be used for the determination of trace Alternaria mycotoxins in liquid food samples.
The enrichment strategy is unique by employing [HOOCMIM][Cl] to modify the solvent system.
The elution of targets by reversing the original stationary phase to mobile phase is quite artful.
The method can provide high recoveries with good reproducibility and low LOD.