The Neutrophil Btk Signalosome Regulates Integrin Activation during Sterile Inflammation
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- 作者：Stephanie Volmering1 ; 3 ; Helena Block1 ; 3 ; Mark Boras1 ; Clifford A. Lowell2 ; Alexander Zarbock1 ; zarbock@uni-muenster.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Btk ; fMLF ; Src family kinases ; phospholipase C ; WASp ; signaling ; integrin
- 刊名：Immunity
- 出版年：2016
- 出版时间：19 January 2016
- 年：2016
- 卷：44
- 期：1
- 页码：73-87
- 全文大小：3121 K
文摘
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Btk is required for neutrophil recruitment during sterile inflammation
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Btk is required for selective fMLF-triggered Mac-1, but not LFA-1, activation
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Hck, WASp, and PLCγ2 are key signaling molecules in the fMLF-triggered pathway
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Btk is required for integrin-mediated outside-in signaling and FcRγ-mediated functions