Discordant diagnostic results due to a hepatitis B virus T123A HBsAg mutant
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文摘

Hepatitis B virus surface antigen (HBsAg) mutations may result in immune escape.

The sT123A mutation was observed to result in diagnostic escape in Canada.

Immunoassay detection of A123 HBsAg was reduced or abolished compared to T123.

Several commercial HBsAg immunoassays are sensitive to the sT123A mutation.

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