Enhanced toxicity and cellular uptake of methotrexate-conjugated nanoparticles in folate receptor-positive cancer cells by decorating with folic acid-conjugated d-α-tocopheryl polyethylene glycol 1000 succinate
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- 作者：Varaporn Buraphacheep Junyapraserta ; b ; varaporn.jun@mahidol.ac.th" class="auth_mail" title="E-mail the corresponding author ; Sirithip Dhanahiranpruka ; Jiraphong Suksiriworaponga ; b ; Kittisak Sriphac ; Primchanien Moongkarndid
- 关键词：d-α-Tocopheryl polyethylene glycol 1000 succinate ; Folic acid ; Methotrexate ; Targeted nanoparticles ; PEGylated poly(ε-caprolactone) ; MCF-7 breast cancer cells
- 刊名：Colloids and Surfaces B: Biointerfaces
- 出版年：2015
- 出版时间：1 December 2015
- 年：2015
- 卷：136
- 期：Complete
- 页码：383-393
- 全文大小：2659 K
文摘
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Biodegradable conjugate of TPGS–FOL was successfully synthesized by click reaction.
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The MTX-conjugated nanoparticles could be decorated by TPGS–FOL.
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10% MTX-conjugated nanoparticles possessed better carrier properties than 20% MTX.
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The nanoparticles could potentiate the toxicity of MTX to cancer cells.
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TPGS–FOL decorated nanoparticles enhanced toxicity and cellular uptake efficiency.