BKPyV NCCR architecture and viral load were analyzed in 35 immunosuppressed subjects.
A distinct rearranged OPQPQQS block was detected in 94.7% of BKPyV HIVSGD NCCRs.
Salivary gland cells support HIVSGD BKPyV promoter activity and replication.
The HIVSGD NCCR may define a BKPyV substrain important to oral BKPyV pathogenesis.