Distinct BK polyomavirus non-coding control region (NCCR) variants in oral fluids of HIV- associated Salivary Gland Disease patients
详细信息 查看全文
- 作者：Raquel Burger-Calderona ; b ; Kathy J. Ramseyc ; Janet M. Dolittle-Hallc ; William T. Seamanc ; Liesl K. Jeffers-Francisd ; Daniel Tesfuc ; Volker Nickeleite ; Jennifer Webster-Cyriaqueb ; c ; f ; cyriaquj@dentistry.unc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：BK polyomavirus ; NCCR ; HIV ; Salivary Gland Disease
- 刊名：Virology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：493
- 期：Complete
- 页码：255-266
- 全文大小：1841 K
文摘
- •
BKPyV NCCR architecture and viral load were analyzed in 35 immunosuppressed subjects.
- •
A distinct rearranged OPQPQQS block was detected in 94.7% of BKPyV HIVSGD NCCRs.
- •
Salivary gland cells support HIVSGD BKPyV promoter activity and replication.
- •
The HIVSGD NCCR may define a BKPyV substrain important to oral BKPyV pathogenesis.