Use of a combined effect model approach for discriminating between ABCB1- and ABCC1-type efflux activities in native bivalve gill tissue
详细信息 查看全文
- 作者：Melissa Fariaa ; b ; Vasiliy Pavlichenkoc ; d ; Kathleen Burkhardt-Medicked ; e ; Amadeu M.V.M. Soaresb ; Rolf Altenburgerd ; Carlos Barataa ; Till Luckenbachd ; till.luckenbach@ufz.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Environment-tissue barrier ; Dreissena polymorpha ; Multixenobiotic resistance ; Multidrug resistance associated protein (MRP) ; P-glycoprotein ; Mixture effect modeling
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2016
- 出版时间：15 April 2016
- 年：2016
- 卷：297
- 期：Complete
- 页码：56-67
- 全文大小：1037 K
文摘
- •
Sequences and function of ABC efflux transporters in bivalve gills were explored.
- •
Full length Dreissena polymorpha abcb1 and abcc1 cDNA sequences were identified.
- •
A mixture effect design with inhibitors was applied in transporter activity assays.
- •
ABCB1- and ABCC-type efflux activities were distinguished in native gill tissue.
- •
Inhibitory action of environmental chemicals targeted ABCB1-type efflux activity.