Dissociations within short-term memory in GluA1 AMPA receptor subunit knockout mice

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• 作者：Amy M. Taylor^a ; Burkhard Niewoehner^a ; Peter H. Seeburg^b ; Rolf Sprengel^b ; J. Nicholas P. Rawlins^a ; David M. Bannerman^a ; David J. Sanderson^a ; ^{david.sanderson@psy.ox.ac.uk"" rel=""nofollow}
• 关键词：AMPA receptors ; Conditional learning ; Trace conditioning ; Non-spatial memory ; Spatial memory
• 刊名：Behavioural Brain Research
• 出版年：2011
• 出版时间：10 October 2011
• 年：2011
• 卷：224
• 期：1
• 页码：8-14
• 全文大小：792 K

文摘

GluA1 AMPA receptor subunit knockout mice display a selective impairment on short-term recognition memory tasks. In this study we tested whether GluA1 is important for short-term memory that is necessary for bridging the discontiguity between cues in trace conditioning. GluA1 knockout mice were not impaired at using short-term memory traces of T-maze floor inserts, made of different materials, to bridge the temporal gap between conditioned stimuli and reinforcement during appetitive discrimination tasks. Thus, different aspects of short-term memory are differentially sensitive to GluA1 deletion. This dissociation may reflect processing of qualitatively different short-term memory traces. Memory that results in performance of short-term recognition (e.g. for objects or places) may be different from the memory required for associative learning in trace conditioning.