HP1BP3, a Chromatin Retention Factor for Co-transcriptional MicroRNA Processing
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- 作者：Haoming Liu1 ; 8 ; Chunyang Liang1 ; 8 ; Rahul K. Kollipara2 ; Masayuki Matsui3 ; Xiong Ke1 ; Byung-Cheon Jeong4 ; Zhiqiang Wang5 ; Kyoung Shin Yoo4 ; Gaya P. Yadav1 ; Lisa N. Kinch6 ; Nicholas V. Grishin6 ; Yunsun Nam4 ; 6 ; David R. Corey1 ; 3 ; Ralf Kittler2 ; Qinghua Liu1 ; 5 ; 7 ; qinghua.liu@utsouthwestern.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：HP1BP3 ; histone H1 ; Drosha-DGCR8 ; pri-miRNA ; co-transcriptional processing
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：4 August 2016
- 年：2016
- 卷：63
- 期：3
- 页码：420-432
- 全文大小：2800 K
文摘
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HP1BP3 is a chromatin protein that promotes global miRNA biogenesis in human cells
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HP1BP3 co-localizes with and promotes Drosha binding at expressed miRNA loci
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HP1BP3 binds DNA and pri-miRNA and facilitates Drosha/pri-miRNA association in vivo
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HP1BP3 retains pri-miRNA on chromatin for co-transcriptional miRNA processing