c21orf59/kurly Controls Both Cilia Motility and Polarization
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- 作者：Kimberly M. Jaffe1 ; 3 ; Daniel T. Grimes1 ; 3 ; Jodi Schottenfeld-Roames1 ; 3 ; Michael E. Werner2 ; Tse-Shuen J. Ku1 ; Sun K. Kim2 ; Jose L. Pelliccia1 ; Nicholas F.C. Morante1 ; Brian J. Mitchell2 ; brian-mitchell@northwestern.edu" class="auth_mail" title="E-mail the corresponding author ; Rebecca D. Burdine1 ; rburdine@princeton.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Kurly (Kur) ; c21orf59 ; cilia ; planar cell polarity ; disheveled ; ciliopathy ; primary ciliary dyskinesia ; multiciliated cell
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：1 March 2016
- 年：2016
- 卷：14
- 期：8
- 页码：1841-1849
- 全文大小：3430 K
文摘
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kurly (kur) mutants exhibit defects characteristic of motile cilia dysfunction
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c21orf59 is mutated in kur and is needed for dynein arm localization/cilia motility
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CRISPR/Cas9 with homologous recombination in Xenopus shows C21orf59 regulates PCP
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C21orf59 interacts with various PCP components to correctly polarize motile cilia