A spontaneous and novel Pax3 mutant mouse that models Waardenburg syndrome and neural tube defects

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• 作者：Tetsuo Ohnishi^a ; ¹ ; ^{tohnishi@brain.riken.jp} ; Ikuo Miura^b ; ¹ ; Hisako Ohba^a ; Chie Shimamoto^a ; Yoshimi Iwayama^a ; Shigeharu Wakana^b ; Takeo Yoshikawa^a
• 关键词：PCR ; polymerase chain reaction ; SNP ; nucleotide polymorphism ; B6N ; C57BL/6N ; B6J ; C57BL6J
• 刊名：Gene
• 出版年：2017
• 出版时间：5 April 2017
• 年：2017
• 卷：607
• 期：Complete
• 页码：16-22
• 全文大小：1272 K
• 卷排序：607

文摘

Spontaneous mutant mouse with poor pigmentation was identified. Up-to-date gene mapping system helped us to identify Pax3 as causal gene. The mutant mice are useful as a model for human Waardenburg syndrome.