Calbindin-D-28K like immunoreactivity in superficial dorsal horn neurons and effects of sciatic chronic constriction injury
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- 作者：M.J. Stebbinga ; S. Balasubramanyanb ; P.A. Smithb ; c ; pas3@ualberta.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cal&minus ; not displaying calbindin-D-28K immunoreactivity ; Cal+ ; displaying calbindin-D-28K immunoreactivity ; CCI ; chronic constriction injury (of sciatic nerve) ; EGTA ; (ethylene glycol tetraacetic acid ; HEPES ; 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid ; K&ndash ; S ; Kolmogorov-Smirnoff (statistics) ; Lamina IIi ; inner portion of substantia gelatinosa ; Lamina IIo ; outer portion of substantia gelatinosa ; NHS ; Normal Horse Serum ; PBS ; phosphate-buffered saline ; sEPSC ; spontaneous excitatory
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：2 June 2016
- 年：2016
- 卷：324
- 期：Complete
- 页码：330-343
- 全文大小：3143 K
文摘
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Calbindin D-28K is found in 30% of neurons in spinal dorsal laminae I and II.
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Calbindin does not associate with specific electrophysiological phenotype.
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Calbindin may associate with putative excitatory neurons and is found in some radial, vertical and central neurons.
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Calbindin containing neurons receive relatively weak excitatory synaptic drive.
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Altered synaptic drive to calbindin neurons does not contribute to central sensitization in neuropathic pain.