Repeated prenatal exposure to valproic acid results in cerebellar hypoplasia and ataxia

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• 作者：Stacey L. Main ; Randy J. Kulesza ; ^{rkulesza@lecom.edu}
• 关键词：ANOVA ; analysis of variance ; ASD ; autism spectrum disorder ; CB ; calbindin ; CB+ ; calbindin immunopositive ; CI ; confidence interval ; ddVPA ; double-dose valproic acid ; E# ; embryonic day # ; HDAC ; histone deacetylase I ; NDS ; normal donkey serum ; P# ; postnatal day # ; PB ; phosphate buffer ; PFA ; paraformaldehyde ; VPA ; valproic acid
• 刊名：Neuroscience
• 出版年：2017
• 出版时间：6 January 2017
• 年：2017
• 卷：340
• 期：Complete
• 页码：34-47
• 全文大小：3164 K
• 卷排序：340

文摘

Prenatal VPA exposure is associated with an increased risk of ASD in humans. VPA exposure resulted in smaller animals with smaller brains and smaller Purkinje cells in the cerebellar vermis. VPA exposure resulted in reduced CB expression throughout the cerebellar vermis and shorter and less complex dendrites. VPA exposure resulted in poor performance in motor tasks but these were attenuated by motor enrichment.