- 作者：Navdeep Khurana ; Ravindra Kumar Garg ; garg50@yahoo.com ; Rajesh Verma ; Hardeep Singh Malhotra ; Maneesh Kumar Singh ; Rakesh Shukla
- 关键词：Albendazole ; Cysticercosis ; Epilepsy ; Neurocysticercosis ; Seizures
- 刊名：Journal of the Neurological Sciences
- 出版年：2012
- 出版时间：15 May, 2012
- 年：2012
- 卷：316
- 期：1-2
- 页码：36-41
- 全文大小：515 K
Background
Albendazole therapy has been found effective in solitary cysticercus granuloma. An optimal duration of albendazole therapy is not exactly known. Even 3-day therapy has been found effective.Methods
We included 105 patients of new-onset seizures and solitary cysticercus granuloma. We compared 3-day albendazole therapy and 15-day therapy with a control group. Each group had 35 patients. This was an open-label randomized trial. Patients were followed for 6 months. MRI was done after 6 months. Seizure recurrences during follow-up were noted.
Results
After 6 months, albendazole group, in comparison to placebo group, had significantly higher proportion (43/70 versus 13/35) of patients in whom lesion had disappeared. Albendazole treatment for 15 days was insignificantly better in comparison to 3-day treatment regimen. In 15-day albendazole group lesser number of lesions (2.8 % ) was calcified than 3-day albendazole group (8.57 % ) or no treatment group (20 % ). After 6 months of follow-up, seizure recurrence was seen in 20 (19 % ) patients. The majority (15/20) of patients, experiencing seizure recurrence, had an abnormal follow-up MRI. Five patients had seizures despite normal MRI.
Conclusion
In conclusion, albendazole was significantly better in producing lesion resolution. A 15-day treatment with albendazole was better than 3-day treatment. Albendazole, possibly, led to less number of lesions got calcified and possibly, there was less risk of seizure recurrence.