Quality of life impacts from rotavirus gastroenteritis on children and their families in the UK

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• 作者：Robin Marlow^a ; ^b ; ^{robin.marlow@bristol.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Adam Finn^a ; ^b ; Caroline Trotter^c
• 关键词：Rotavirus ; Quality of life ; Great Britain ; Rotavirus vaccines ; Economic evaluation
• 刊名：Vaccine
• 出版年：2015
• 出版时间：22 September 2015
• 年：2015
• 卷：33
• 期：39
• 页码：5212-5216
• 全文大小：473 K

文摘

Rotavirus vaccines (RV) are safe and effective but demand significant investment of healthcare resource. In countries with low mortality due to rotavirus, a key component to assessing cost-effectiveness is quantifying the Health Related Quality of Life (HRQoL) lost due to rotavirus acute gastroenteritis (RVAGE).

Methods

Families with children less than six years old with gastroenteritis were recruited from attendees to Bristol Children's Hospital Emergency Department. Stools were tested for viral causes of gastroenteritis. Children's HRQoL was assessed at presentation using Health Utilities Index 2 (HUI2) with visual analogue scale (VAS). The effect of the child's illness on the HRQoL of up to two adult carers was assessed using EQ-5D-5L. Families completed a daily symptom diary to assess time to recovery and within-family transmission.

Results

127 families consented to take part, 84(65%) had rotavirus as the cause of illness. At the time of attendance, mean paediatric HRQoL with RVAGE was 0.74(HUI2) and 0.42(VAS). Primary/secondary carer's HRQoL was 0.68/0.80 (EQ5D) or 0.70/0.79 (VAS). The mean number of QALYs lost due to RVAGE was 3.1–3.5 per thousand children and 7.7–8.7 per thousand family units.

In 52% of RVAGE families at least one other member developed a secondary case of gastroenteritis. For working parents, 69% missed work, for a mean of 2.8 days (95% CI 2.3–3.4).

Conclusions

We have found the HRQoL loss associated with RVAGE in children and their carers to be significantly higher than estimates used for all RV medical attendances in UK cost-effectiveness calculations.