Pathophysiology, Evaluation, and Management of Chronic Watery Diarrhea

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• 作者：Michael Camilleri¹ ; ^{camilleri.michael@mayo.edu} ; Joseph H. Sellin² ; Kim E. Barrett³
• 关键词：Diarrhea ; Pathophysiology ; Management
• 刊名：Gastroenterology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：152
• 期：3
• 页码：515-532.e2
• 全文大小：1603 K
• 卷排序：152

文摘

Chronic watery diarrhea poses a diagnostic and therapeutic challenge and is often a disabling condition for patients. Although acute diarrhea is likely to be caused by infection, the causes of chronic diarrhea (>4 weeks in duration) are more elusive. We review the pathophysiology, diagnosis, and treatment of chronic diarrhea. Drawing on recent insights into the molecular mechanisms of intestinal epithelial transport and barrier function, we discuss how diarrhea can result from a decrease in luminal solute absorption, an increase in secretion, or both, as well as derangements in barrier properties. We also describe the various extraepithelial factors that activate diarrheal mechanisms. Finally, clinical evaluation and tests used in the assessment of patients presenting with chronic diarrhea are reviewed, and an algorithm guiding therapeutic decisions and pharmacotherapy is presented.