Human neutrophil peptide-1 affects matrix metalloproteinase-2, -8 and -9 secretions of oral squamous cell carcinoma cell lines in vitro
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- 作者：Ahmed Ali Musratia ; ahsamu@utu.fi" class="auth_mail" title="E-mail the corresponding author ; Taina Tervahartialab ; Mervi Gü ; rsoya ; Eija Kö ; nö ; nena ; Dareen Fteitaa ; Timo Sorsab ; c ; Veli-Jukka Uittob ; Ulvi Kahraman Gü ; rsoya
- 关键词：Antimicrobial peptide ; In vitro experiment ; MMPs ; Oral cancer
- 刊名：Archives of Oral Biology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：66
- 期：Complete
- 页码：1-7
- 全文大小：1280 K
文摘
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HNP-1 enhances cell death of OSCC cell lines in a dose- and time- dependent manner.
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HNP-1 down-regulates the expression of MMP-2, -8, and -9 in these cell lines.
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To conclude, HNP-1 might modify the progression of oral cancerous cells through its effect on MMP-2, -8, and -9 secretions.