Integrative genomic and functional analysis of human oral squamous cell carcinoma cell lines reveals synergistic effects of FAT1 and CASP8 inactivation
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- 作者：Tyler F. Hayesa ; Nathan Benaicha ; Stephen J. Goldieb ; Kalle Sipilä ; a ; Ashley Ames-Draycotta ; Wenjun Caic ; Guangliang Yinc ; Fiona M. Watta ; Fiona.watt@kcl.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Oral squamous cell carcinoma ; Caspase 8 ; FAT1 ; Whole exome sequencing
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：1 December 2016
- 年：2016
- 卷：383
- 期：1
- 页码：106-114
- 全文大小：4098 K
文摘
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Generation of human oral squamous cell carcinoma lines with whole exome sequence data.
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Mutational spectrum of the lines is representative of primary tumours.
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Loss of function mutations in FAT1 and CASP8 frequently co-occur.
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Inactivating FAT1 mutations correlate with reduced intercellular adhesion.
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Inactivation of FAT1 and CASP8 results in increased clonal growth, migration and apoptosis resistance.