Generation of human oral squamous cell carcinoma lines with whole exome sequence data.
Mutational spectrum of the lines is representative of primary tumours.
Loss of function mutations in FAT1 and CASP8 frequently co-occur.
Inactivating FAT1 mutations correlate with reduced intercellular adhesion.
Inactivation of FAT1 and CASP8 results in increased clonal growth, migration and apoptosis resistance.