CARMA3 Is a Host Factor Regulating the Balance of Inflammatory and Antiviral Responses against Viral Infection
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- 作者：Changying Jiang1 ; 7 ; Zhicheng Zhou1 ; 2 ; 7 ; Yanping Quan1 ; 8 ; Shilei Zhang3 ; Tingting Wang1 ; Xueqiang Zhao3 ; Clayton Morrison4 ; Mark T. Heise4 ; Wenqian He5 ; Matthew S. Miller6 ; Xin Lin1 ; 2 ; 3 ; xllin@mdanderson.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：CARMA3 ; CARD10 ; IRF3 ; NF-κB ; viral infection
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：15 March 2016
- 年：2016
- 卷：14
- 期：10
- 页码：2389-2401
- 全文大小：3273 K
文摘
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Deficiency of CARMA3 results in the host resistance to RNA viral infection
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CARMA3 positively regulates RIG-I/MAVS-mediated NF-κB activation
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CARMA3 negatively regulates RIG-I/MAVS-mediated TBK1/IRF3 activation
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CARMA3 negatively suppresses MAVS oligomerization in mitochondran