MALT1 Protease Activation Triggers Acute Disruption of Endothelial Barrier Integrity via CYLD Cleavage
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- 作者：Linda R. Klei1 ; 8 ; Dong Hu1 ; 8 ; Robert Panek2 ; 8 ; Danielle N. Alfano1 ; Rachel E. Bridwell1 ; Kelly M. Bailey3 ; Katherine I. Oravecz-Wilson2 ; Vincent J. Concel1 ; Emily M. Hess1 ; Matthew Van Beek2 ; Phillip C. Delekta2 ; Shufang Gu2 ; Simon C. Watkins4 ; Adrian T. Ting5 ; Peter J. Gough6 ; Kevin P. Foley6 ; John Bertin6 ; Linda M. McAllister-Lucas1 ; 7 ; linda.mcallister@chp.edu" class="auth_mail" title="E-mail the corresponding author ; Peter C. Lucas1 ; 7 ; 9 ; lucaspc@upmc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：NF-κB ; thrombin ; Protease activated receptor-1 (PAR1) ; CARMA3 ; CARD10 ; Bcl10 ; G protein-coupled receptor (GPCR) ; endothelial permeability ; MALT1 protease ; CYLD
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：27 September 2016
- 年：2016
- 卷：17
- 期：1
- 页码：221-232
- 全文大小：4315 K
文摘
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Thrombin induces MALT1 protease activity in endothelial cells
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MALT1-dependent cleavage of CYLD initiates microtubule disruption
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Blocking MALT1 protease activity or CYLD cleavage reduces endothelial permeability
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Mice harboring catalytically inactive MALT1 are protected from pulmonary edema