Ideal cardiovascular health influences cardiovascular disease risk associated with high lipoprotein(a) levels and genotype: The EPIC-Norfolk prospective population study

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• 作者：Nicolas Perrot^a ; ^b ; Rutger Verbeek^c ; Manjinder Sandhu^d ; ^e ; S. Matthijs Boekholdt^f ; G. Kees Hovingh^c ; Nicholas J. Wareham^g ; Kay-Tee Khaw^d ; Benoit J. Arsenault^a ; ^b ; ^{benoit.arsenault@criucpq.ulaval.ca}
• 关键词：Lipoprotein(a) ; Lifestyle ; Genetics ; Ideal cardiovascular health ; Cardiovascular diseases
• 刊名：Atherosclerosis
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：256
• 期：Complete
• 页码：47-52
• 全文大小：363 K
• 卷排序：256

文摘

Elevated lipoprotein(a) levels is one of the strongest genetic risk factors for CVD. Few health professionals routinely measure Lp(a) presumably because there are no therapeutic agents available to lower Lp(a). Clinical and lifestyle-related factors do not appear to influence Lp(a) levels at the population level. Individuals with high Lp(a) levels who control clinical and lifestyle-related risk factors have a lower risk of CVD. Targeting clinical and lifestyle-related risk factors could reduce cardiovascular risk in individuals with high Lp(a) levels.