- 作者：Elisabetta Esposito ; Laura Ravani ; Paolo Mariani ; Catia Contado ; Markus Drechsler ; Carmelo Puglia ; Rita Cortesi
- 关键词：MAD ; monoolein aqueous dispersions ; CR ; curcumin ; SdFFF ; Sedimentation Field Flow Fractionation ; cryo-TEM ; Cryo-Transmission Electron Microscopy ; SCE ; stratum corneum epidermis
- 刊名：Materials Science and Engineering: C
- 出版年：2013
- 出版时间：1 December, 2013
- 年：2013
- 卷：33
- 期：8
- 页码：4923-4934
- 全文大小：7383 K
MAD based on monoolein and different emulsifiers have been produced and characterized. Morphology and dimensional distribution have been investigated by Cryogenic Transmission Electron Microscopy (cryo-TEM), X-ray and Photon Correlation Spectroscopy (PCS).
Monoolein in different mixtures with sodium cholate, sodium caseinate, bentonite and poloxamer resulted in heterogeneous dispersions constituted of unilamellar vesicles, cubosomes and sponge type phases, depending on the employed components, as found by cryo-TEM and X-ray studies. CR was encapsulated with entrapment efficiencies depending on the MAD composition, particularly the highest was reached in the case of monoolein/poloxamer/sodium cholate mixture. The same mixture was able to maintain CR stability also after 6 months.
CR release modalities were in vitro investigated in order to mimic a possible subcutaneous administration of MAD. It was found that MAD constituted of monoolein/poloxamer and monoolein/poloxamer/sodium cholate mixtures were able to sustain CR release.
MAD viscous vehicles were produced by xanthan gum.
CR percutaneous absorption has been studied in vitro using excised human skin membranes [stratum corneum epidermis (SCE)] mounted into Franz cells. It was found that fluxes (Fn) of CR incorporated in MAD are influenced by the presence of monoolein based nanosystems. In particular xanthan gum based MAD better control CR diffusion from MAD.