Regulation of T Cell Receptor Signaling by DENND1B in TH2 Cells and Allergic Disease
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- 作者：Chiao-Wen Yang1 ; 6 ; Caroline D. Hojer1 ; 6 ; Meijuan Zhou2 ; Xiumin Wu2 ; Arthur Wuster3 ; 4 ; Wyne P. Lee2 ; Brian L. Yaspan3 ; Andrew C. Chan5 ; acc@gene.com" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell
- 出版年：2016
- 出版时间：14 January 2016
- 年：2016
- 卷：164
- 期：1-2
- 页码：141-155
- 全文大小：5374 K
文摘
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DENND1B is required for efficient downmodulation of the TCR in TH2 cells
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Dennd1b−/− TH2 cells exhibit delayed TCR downmodulation and enhanced signaling
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Human TH2 cells with DENND1B SNPs associated with asthma mimic Dennd1b−/− TH2 cells
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DENND1B association with Rab35 and CD3ε is increased with TCR activation in TH2 cells