Synthesis, characterization and radiolabeling of folic acid modified nanostructured lipid carriers as a contrast agent and drug delivery system

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• 作者：Eser Ucar^a ; Serap Teksoz^a ; ^{serap.teksoz@ege.edu.tr} ; Cigdem Ichedef^a ; Ayfer Yurt Kilcar^a ; E. Ilker Medine^a ; Kadir Ari^a ; Yasemin Parlak^b ; B. Elvan Sayit Bilgin^b ; Perihan Unak^a
• 关键词：Radiolabeling ; Paclitaxel ; Nanostructured lipid carriers ; Technetium-99  ; m ; Cell culture ; Biodistribution
• 刊名：Applied Radiation and Isotopes
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：119
• 期：Complete
• 页码：72-79
• 全文大小：986 K
• 卷排序：119

文摘

Proposal of 99 mTc carbonyl-labeled and active targeted nanostructured lipid carriers as a multifunctional system. Cytotoxicity and fluorescence imaging studies for nanoparticles were evaluated on lung, cervical and breast cancer cell lines. In vitro cell binding studies were performed for radiolabeled carrier system. Tissue distribution of 99 mTc carbonyl-labeled nanoparticles was investigated on female Wistar Albino rats by Biodistribution and gamma imaging studies.