In vivo imaging of brain glutamate defects in a knock-in mouse model of Huntington's disease
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- 作者：Jé ; ré ; my Pé ; pina ; b ; Laetitia Francellea ; b ; Maria-Angeles Carrillo-de Sauvagea ; b ; Lucie de Longpreza ; b ; Pauline Gipchteina ; b ; Karine Cambona ; b ; Julien Valettea ; b ; Emmanuel Brouilleta ; b ; Julien Flamenta ; c ; julien.flament@cea.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Chemical exchange saturation transfer ; GluCEST ; Huntington's disease ; Glutamate ; Mouse model ; Neurodegenerative disease
- 刊名：NeuroImage
- 出版年：2016
- 出版时间：1 October 2016
- 年：2016
- 卷：139
- 期：Complete
- 页码：53-64
- 全文大小：1484 K
文摘
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A knock-in mouse model of Huntington's disease Ki140CAG is characterized.
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Behavioral tests, MRS and glutamate imaging reveal significant alterations in mice.
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The glutamate distribution is mapped in vivo into the brain using gluCEST imaging.
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GluCEST imaging is proposed as a potential biomarker of Huntington's disease.