Copper-catalyzed ligand free ring-opening amination of gem-fluorohalocyclopropanes - An efficient route toward 2-fluoroallylamines

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• 作者：Maxim A. Novikov^a ; ^b ; ^{manovikov@ioc.ac.ru} ; Yaroslav A. Ibatov^b ; Nikolai V. Volchkov^a ; Maria B. Lipkind^a ; Sergei E. Semenov^b ; Oleg M. Nefedov^a ; ^{nefedov@ioc.ac.ru}
• 关键词：gem-Fluorohalocyclopropanes ; Fluorohalocarbenes ; Copper catalysis ; 2-Fluoroallyl amines ; Ring-opening amination ; Cyclopropyl-allylic transformation
• 刊名：Journal of Fluorine Chemistry
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：194
• 期：Complete
• 页码：58-72
• 全文大小：1469 K
• 卷排序：194

文摘

Copper-catalyzed cyclopropyl-allylic rearrangements of gem-fluorohalocyclopropanes. An effective approach to aryl-, alkyl substituted tertiary 2-fluoroallyl amines. Preparation of secondary 2-fluoroallyl amines using PMP-protective group. Synthesis of primary 2-fluoroallyl amines by Gabriel or Delepin amination of halides.