XDR-TB transmission in London: Case management and contact tracing investigation assisted by early whole genome sequencing
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- 作者：Amber Arnolda ; b ; amber.arnold@doctors.org.uk" class="auth_mail" title="E-mail the corresponding author ; Adam A. Witneya ; awitney@sgul.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Stephania Vergnanoa ; stev@doctors.org.uk" class="auth_mail" title="E-mail the corresponding author ; Anita Rochec ; anita.roche@phe.gov.uk" class="auth_mail" title="E-mail the corresponding author ; Catherine A. Cosgrovea ; b ; ccosgrov@sgul.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Angela Houstonb ; angela.houston@stgeorges.nhs.uk" class="auth_mail" title="E-mail the corresponding author ; Katherine A. Goulda ; kgould@sgul.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Jason Hindsa ; jhinds@sgul.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Peter Rileyb ; peter.riley@stgeorges.nhs.uk" class="auth_mail" title="E-mail the corresponding author ; Derek Macallana ; b ; macallan@sgul.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Philip D. Butchera ; butercherp@sgul.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Tom S. Harrisona ; b ; tharriso@sgul.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Tuberculosis ; Drug resistance ; Contact tracing ; Disease outbreaks ; Pathology ; molecular
- 刊名：Journal of Infection
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：73
- 期：3
- 页码：210-218
- 全文大小：314 K
文摘
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This is the first report in the UK of a complex XDR-TB cluster.
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Methods for 2-year follow-up of contacts and active cases are presented.
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Early whole genome sequencing (WGS) enables individualized treatment of cases.
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WGS identifies transmission events and assists rapid public health interventions.