Effect of Exercise and Antidepressants on Skeletal Outcomes in Adolescent Girls With Anorexia Nervosa

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• 作者：Amy D. DiVasta ; M.D. ; M.M.Sc.^a ; ^b ; ^{amy.divasta@childrens.harvard.edu} ; Henry A. Feldman ; Ph.D.^c ; ^d ; Jennifer M. O'Donnell^e ; Jin Long ; Ph.D.^f ; Mary B. Leonard ; M.D.^f ; Catherine M. Gordon ; M.D. ; M.Sc.^g
• 关键词：Anorexia nervosa ; Malnutrition ; Peripheral quantitative computed tomography ; DXA ; Exercise ; Antidepressant
• 刊名：Journal of Adolescent Health
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：60
• 期：2
• 页码：229-232
• 全文大小：322 K
• 卷排序：60

文摘

We examined the relationships between malnutrition, lifestyle factors, and bone health in anorexia nervosa (AN) via dual-energy X-ray absorptiometry (DXA) and peripheral quantitative computed tomography (pQCT).MethodsSeventy adolescent girls with AN and 132 normal-weighted controls underwent pQCT tibial measures including trabecular volumetric bone mineral density (vBMD), cortical vBMD, and cortical thickness. Participants with AN underwent DXA measures of the axial skeleton. We assessed the association of DXA and pQCT measures with clinical and lifestyle variables.ResultsBody mass index Z-score and ideal body weight percentage were positively correlated with trabecular vBMD, cortical CSA, and section modulus (p < .04). Exercise was associated with all pQCT measures but only with hip BMD by DXA. In AN, the use of antidepressants was associated with lower pQCT measures (p < .03).ConclusionsAntidepressants may negatively, and exercise positively, influence BMD in adolescents with eating disorders. These findings offer a provocative look at two longstanding questions.