Andrographolide inhibits adipogenesis of 3T3-L1 cells by suppressing C/EBPβ expression and activation
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- 作者：Ching-Chu Chena ; b ; 1 ; Wei-Ting Chuangc ; 1 ; Ai-Hsuan Linc ; Chia-Wen Tsaic ; Chin-Shiu Huangd ; e ; Yun-Ting Chenc ; Haw-Wen Chenc ; chenhw@mail.cmu.edu.tw" class="auth_mail" title="E-mail the corresponding author ; Chong-Kuei Liic ; d ; cklii@mail.cmu.edu.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：CDK ; cyclin-dependent kinase ; CREB ; cAMP response element-binding protein ; C/EBP ; CCAAT/enhancer-binding protein ; EMSA ; electrophoretic mobility shift assay ; ERK ; extracellular signal-regulated kinases ; FAS ; fatty acid synthase ; GSK ; glycogen synthase kinase ; IBMX ; 3-isobutylmethoxylxanthine ; MCE ; mitotic clonal expansion ; PKA ; protein kinase A ; PPAR ; peroxisome proliferator-activated receptor ; SCD ; stearoyl-CoA desaturase
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2016
- 出版时间：15 September 2016
- 年：2016
- 卷：307
- 期：Complete
- 页码：115-122
- 全文大小：935 K
文摘
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Andrographolide is a diterpenoid phytochemical.
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Andrographolide inhibits adipogenesis of 3 T3-L1 adipocytes.
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Andrographolide suppresses differentiation cocktail-induced C/EBPβ expression.
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Andrographolide attenuates ERK and GSK3β-dependent C/EBPβ activation.
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Andrographolide arrests 3 T3-L1 adipocytes at G0/G1 phase.