IL-17A synergistically enhances TNFα-induced IL-6 and CCL20 production in 3T3-L1 adipocytes
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- 作者：Takanori Shinjoa ; Misaki Iwashitaa ; Akiko Yamashitaa ; Tomomi Sanoa ; Mitsudai Tsurutaa ; Hiroaki Matsunagaa ; Terukazu Sanuia ; Tomoichiro Asanob ; Fusanori Nishimuraa ; fusanori@dent.kyushu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：IL-17A ; 3T3-L1 adipocyte ; IL-6 ; CCL20 ; Synergy
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：19 August 2016
- 年：2016
- 卷：477
- 期：2
- 页码：241-246
- 全文大小：862 K
文摘
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IL-17A synergizes with TNFα to enhance IL-6 secretion by 3T3-L1 adipocytes.
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Both NF-κB and AP-1 signal pathways play crucial roles in the synergy.
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TNFα-induced IL-17RA mRNA levels are enhanced in 3T3-L1 adipocytes by IL-17A.
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TNFα-induced CCL20 secretion in 3T3-L1 adipocytes is enhanced by IL-17A.
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CCL20 serum levels are increased in HFD-fed mice and KKAy/Ta mice.