CCL5 deficiency reduces neointima formation following arterial injury and thrombosis in apolipoprotein E-deficient mice
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- 作者：Frauke S. Czeplucha ; f.czepluch@med.uni-goettingen.de" class="auth_mail" title="E-mail the corresponding author ; Julia Meiera ; Claudia Binderb ; Gerd Hasenfussa ; Katrin Schä ; fera ; c
- 关键词：ApoE ; Arterial thrombosis ; CCL5 ; KLF4 ; Neointima
- 刊名：Thrombosis Research
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：144
- 期：Complete
- 页码：136-143
- 全文大小：2878 K
文摘
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We examined how CCL5 deficiency affects postthrombotic vascular remodeling.
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CCL5 deficiency decreased neointima formation after carotid injury in ApoE−/− mice.
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Reduced neointima formation was not the result of differences in thrombus formation.
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Atheroprotective effects of CCL5 deficiency may involve changes in KLF4 expression.