miR-22 suppresses the proliferation and invasion of gastric cancer cells by inhibiting CD151

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• 作者：Xun Wang^a ; Honggang Yu^a ; ^{honggang_yuwh@163.com" class="auth_mail} ; Xinyao Lu^b ; Peng Zhang^b ; Minglin Wang^b ; Yikui Hu^c
• 关键词：miR-22 ; Gastric cancer ; CD151 ; Proliferation ; Migration ; Invasion
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：28 February, 2014
• 年：2014
• 卷：445
• 期：1
• 页码：175-179
• 全文大小：1103 K

文摘

Gastric cancer (GC) is the second common cause of cancer-related death worldwide. microRNAs (miRNAs) play important roles in the carcinogenesis of GC. Here, we found that miR-22 was significantly decreased in GC tissue samples and cell lines. Ectopic overexpression of miR-22 remarkably suppressed cell proliferation and colony formation of GC cells. Moreover, overexpression of miR-22 significantly suppressed migration and invasion of GC cells. CD151 was found to be a target of miR-22. Furthermore, overexpression of CD151 significantly attenuated the tumor suppressive effect of miR-22. Taken together, miR-22 might suppress GC cells growth and motility partially by inhibiting CD151.